Israel and Hezbollah have exchanged fire for over a year in parallel with the Gaza war but fighting has dramatically escalated since late September, with Israeli troops intensifying bombing on swathes of Lebanon's south and east and making ground incursions into border villages.
About 20 Israeli strikes on the Baalbek-Hermel governorate killed 30 people and wounded 35, governor Bachir Khodr said on X.
The Israeli military did not immediately comment.
Israeli strikes have also battered Hezbollah strongholds in the southern suburbs of the capital Beirut.
At least four strikes targeted the area on Wednesday after the Israeli military ordered residents to leave several locations.
There was no immediate report on casualties or details on what was hit.
The attack happened shortly after Hezbollah secretary general Naim Qassem said he did not believe that "political action" would bring about an end to hostilities.
He said there could be a road to indirect negotiations if Israel stopped its attacks.
Lebanese rescuers have scoured a destroyed building in the town of Barja south of Beirut. (AP PHOTO)
"When the enemy decides to stop the aggression, there is a path for negotiations that we have clearly defined - indirect negotiations through the Lebanese state and Speaker (of parliament Nabih) Berri," Qassem said.
US diplomatic efforts to halt fighting between Israel and Hezbollah, which included a 60-day ceasefire proposal, faltered last week ahead of the US election in which former president Donald Trump recaptured the White House.
More than 3000 people have been killed in Israeli strikes on Lebanon over the last year, the vast majority in the past six weeks.
Lebanese rescuers scoured a destroyed apartment building in the town of Barja south of Beirut for bodies or any survivors after an Israeli strike on Tuesday evening that killed 20 people there, Lebanon's health ministry said.
Moussa Zahran, who lived on one of the upper floors of the building, returned to sift through the ruins of his home.
His burned feet were wrapped in gauze and his son and wife were in hospital after being wounded in the strike.
"These rocks that you see here weigh 100 kilos, they fell on a 13 kilo kid," he said, referring to his son and the apartment wall that had collapsed onto him during the strike.
It was not immediately clear if the strike targeted a member of Hezbollah.
There was no evacuation warning ahead of the air raid.
🚨Sirens sounding across central and northern Israel due to projectiles fired by Hezbollah — Israel Defense Forces (@IDF) pic.twitter.com/mKI0yPvkEYNovember 6, 2024
Hezbollah said on Wednesday it had fired missiles at an Israeli military base near Ben Gurion Airport.
Israeli media reported a rocket had landed near the airport.
Later, the Israeli military said dozens of "projectiles" had crossed into Israel from Lebanon, some of which were intercepted.
Efforts to bring a diplomatic end to the conflict have stalled.
Israeli Prime Minister Benjamin Netanyahu on Tuesday appointed Israel Katz as his new defence minister, who vowed to "defeat" Hezbollah so that people displaced from northern Israel could return home.
Berri - a Hezbollah ally and diplomatic interlocutor - met the US and Saudi ambassadors to Lebanon on Wednesday to discuss political developments, his office said, without providing further details.
