Benalla Neighbourhood Policing Team executed a search warrant on a Thomas St, Benalla, property about 8.40am on May 15.
Police seized what is alleged to be cocaine, 1,4-Butanediol, and two cannabis plants from the house.
A 23-year-old Wangaratta woman was arrested at the scene.
Police located a vehicle of interest on Waller St shortly after. A 26-year-old man and a 21-year-old man, both from Benalla, were arrested.
It is alleged keys believed to be stolen during a burglary in Cobram on May 13 were inside the vehicle.
The Wangaratta woman was issued a caution. The 21-year-old man was released without charge.
The 26-year-old man was charged with trafficking and possessing cocaine, cultivating and possessing cannabis, possessing 1,4-Butanediol, possessing schedule four poison, possessing equipment used in trafficking a drug of dependence, possessing proceeds of crime, and failing to comply with direction by a magistrate.
He was charged and bailed to appear at Benalla Magistrates' Court on September 10.