An unbeaten half-century from South Australia's Nathan McSweeney has left Sheffield Shield leaders Western Australia facing a mountain to climb at the Adelaide Oval.
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The Redbacks extended their lead to 400, reaching 5-124 at lunch on day three on Sunday.
After conceding a mammoth 276-run first innings deficit, WA gave themselves some hope late on day two with two key wickets.
But South Australia scored quickly during Sunday's morning session despite shedding three more wickets.
McSweeny proved to be the mainstay and hit nine boundaries in his 59 not out.
Thomas Kelly was the other batter at the crease, unbeaten on two.
Nightwatchman Wes Agar was the first to go without scoring before opener Henry Hunt went for 27.
Spinner Corey Rocchiccioli picked up the wicket of the dangerous Jake Lehmann for 18 just prior to the lunch break.
South Australia are chasing a rare win over a Western Australia side sitting clear at the top of the standings with four wins from six matches this season.